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The MCA Campus is located in south central El Paso in one of the poorest zip codes in the country. The medical campus started emerging in this blighted part of town due to the fact that the county hospital and TTUHSC clinics were already located in the area and local philanthropists donated the land adjacent to the county hospital for the development of the new medical school.

The MCA Foundation was founded in 2006 for the purpose of creating an integrated campus of medical facilities along the border. That campus would later become known as the Medical Center of the Americas.